Category Archives: Organ (anatomy)
Hemp Seed and Hemp Seed Oil ~ a superfood, but not a cancer cure…
Hemp Seed and Hemp Seed Oil
~ a superfood, but not a cancer cure…
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Not to be confused with hash oil.
Is Hemp SEED oil the same as the cannabis cure oil?
NO! they are produced in entirely different methods from different parts and even different sexes of the plant!!! While I do recommend people cook with hemp seed oil whenever possible, It is not the cure for cancer. It is “health food” because its 3:1 ratio of omega-6 to omega-3 essential fatty acids, which matches the balance required by the human body. If you need more protein, I suggest eating raw shelled hemp seeds. Any vegetarian having trouble getting enough protein in their diet should buy some. A serving of 3 tablespoons packs 10 grams of protein.
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What is Hemp Seed Oil?
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Bottles of hempseed oil
Hemp oil or hempseed oil is obtained by pressing hemp seeds. Cold pressed, unrefined hemp oil is dark to clear light green in color, with a pleasant nutty flavour. The darker the color, the grassier the flavour.
Refined hempseed oil is clear and colorless, with little flavor and lacks natural vitamins and antioxidants. Refined hempseed oil is primarily used in body care products. Industrial hempseed oil is used in lubricants, paints, inks, fuel, and plastics. Hempseed oil has found some limited use in the production of soaps, shampoos and detergents. The oil is of high nutritional value because its 3:1 ratio of omega-6 to omega-3 essential fatty acids, which matches the balance required by the human body.[1] It has also received attention in recent years as a possible feedstock for the large-scale production of biodiesel.[2][3] There are a number of organisations that promote the production and use of hempseed oil.[4]
Hemp seed oil (right)
Hempseed oil is manufactured from varieties of Cannabis sativa that do not contain significant amounts of THC, the psychoactive element present in the cannabis plant. This manufacturing process typically includes cleaning the seed to 99.99% before pressing the oil. There is no THC within the hempseed, although trace amounts of THC may be found in hempseed oil when plant matter adheres to the seed surface during manufacturing. The modern production of hempseed oil, particularly in Canada, has successfully lowered THC values since 1998.[5]Hash oil, not to be confused with hempseed oil, is used for both medicinal and recreational purposes and made from the mature female flowers and leaves of the drug cannabis, thus having a much higher THC content. Hash oil should not be confused with hemp, as the modern usage of the word ‘hemp’ is reserved for plants that meet the legal requirement of containing 0.3% THC or less.[citation needed]_____________________________
Nutrition
About 30–35% of the weight of hempseed is an edible oil that contains about 80% as essential fatty acids (EFAs); i.e., linoleic acid,omega-6 (LA, 55%), alpha-linolenic acid, omega-3 (ALA, 22%), in addition to gamma-linolenic acid, omega-6 (GLA, 1–4%) andstearidonic acid, omega-3 (SDA, 0–2%).
The proportions of linoleic acid and alpha-linolenic acid in one tablespoon per day (15 ml) of hempseed oil easily provides human daily requirements for EFAs. Unlike flaxseed oil, hempseed oil can be used continuously without developing a deficiency or other imbalance of EFAs. This has been demonstrated in a clinical study, where the daily ingestion of flaxseed oil decreased the endogenous production of GLA.[6]In common with other oils, hempseed oil provides 9 kcal/g. Compared with other culinary oils it is low in saturated fatty acids.[7]Highly unsaturated oils, and especially poor quality oils, can spontaneously oxidize and turn rancid within a short period of time when they are not stored properly; i.e., in a cool/cold, dark place, preferably in a dark glass bottle. Hempseed oil can be frozen for longer periods of storage time. Preservatives (antioxidants) are not necessary for high-quality oils that are stored properly.
Hempseed oil has a relatively low smoke point and is not suitable for frying. Hempseed oil is primarily used as a food oil and dietary supplement, and has been shown to relieve the symptoms of eczema (atopic dermatitis).[8]Benefits
Hemp is a high protein seed containing all nine of the essential amino acids (like flax). It also has high amounts of fatty acids and fiber as well as containing vitamin E and trace minerals. It has a balanced ratio of omega 3 to 6 fats at around a three to one ratio. This won’t help correct your omega balance if it’s off, but it gives you the right balance to start with.
Further the protein content of the hemp seed is supposed to be very digestible. Many people noted their personal experience of finding that hemp seed protein did not cause bloating or gas, like some of their whey, or other protein shakes did.
And, get this, unlike soy which has super high amounts of phytic acid (that anti-nutrient that prevents us from absorbing minerals), hemp seed doesn’t contain phytic acid. At the very least, this makes hemp seed a step up from soy.
The Body Ecology Diet site has an article discussing hemp here.
It contains a list of benefits including what I mentioned above plus including some others as well.
Hemp contains:
* All 20 amino acids, including the 9 essential amino acids (EAAs) our bodies cannot produce.
* A high protein percentage of the simple proteins that strengthen immunity and fend off toxins.
* Eating hemp seeds in any form could aid, if not heal, people suffering from immune deficiency diseases. This conclusion is supported by the fact that hemp seed has been used to treat nutritional deficiencies brought on by tuberculosis, a severe nutrition blocking disease that causes the body to waste away.3
* Nature’s highest botanical source of essential fatty acid, with more essential fatty acid than flax or any other nut or seed oil.
* A perfect 3:1 ratio of Omega-6 Linoleic Acid and Omega-3 Linolenic Acid – for cardiovascular health and general strengthening of the immune system.
* A superior vegetarian source of protein considered easily digestible.
* A rich source of phytonutrients, the disease-protective element of plants with benefits protecting your immunity, bloodstream, tissues, cells, skin, organs and mitochondria.
* The richest known source of polyunsaturated essential fatty acids.
This article claims that because hemp’s protein is in the globulin edistin form it is a superior source of protein. It ends that thought with this paragraph.
“The best way to insure the body has enough amino acid material to make the globulins is to eat foods high in globulin proteins. Since hemp seed protein is 65% globulin edistin, and also includes quantities of albumin, its protein is readily available in a form quite similar to that found in blood plasma. Eating hemp seeds gives the body all the essential amino acids required to maintain health, and provides the necessary kinds and amounts of amino acids the body needs to make human serum albumin and serum globulins like the immune enhancing gamma globulins. Eating hemp seeds could aid, if not heal, people suffering from immune deficiency diseases. This conclusion is supported by the fact that hemp seed was used to treat nutritional deficiencies brought on by tuberculosis, a severe nutrition blocking disease that causes the body to waste away. [Czechoslovakia Tubercular Nutritional Study, 1955] “
reference for above centered “benefits section):
http://www.thenourishinggourmet.com/2009/03/hemp-seed-nutritional-value-and-thoughts.html
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[edit]Wood finish
Hemp oil is a “drying oil”, as it can polymerize into a solid form. Due to its polymer-forming properties, hemp oil is used on its own or blended with other oils, resins, and solvents as an impregnator and varnish in wood finishing, as a pigment binder in oil paints, as a plasticizer and hardener in putty. It has uses similar to Linseed oil and characteristics similar totung oil.[9]click here for reference information for the above hemp seed oil portion of the post
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Is there a difference between Hemp and Cannabis?
Yes and no… Hemp generally refers to either the male plant or the portions of the plant used for their fiber. Cannabis generally refers to the female plant and the portions of the plant used for it’s psychoactive and healing effects.
Merriam-Webster definitions of Hemp and Cannabis:
noun ˈhemp
1
b : the fiber of hemp
c : a psychoactive drug (as marijuana or hashish) from hemp
2
: a fiber (as jute) from a plant other than the true hemp;
also: a plant yielding such fiber
Origin of HEMP
Middle English, from Old English hænep;
akin to Old High German hanaf hemp,
Greek kannabis
First Known Use: before 12th century
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Origin of CANNABIS
Latin, hemp, from Greek kannabis; akin to Old English hænephemp
First Known Use: 1783
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Author’s note ~ there is so much more to know on the origin of the word Cannabis!!!
If you do your homework on cannabis well,
you should have come across kaneh-bosim (Hebrew קְנֵה-בֹשֶׂם)
The anthropologist Sula Benet did a lot of work
on the etymology of this word and it’s association
with Old Testament biblical recipe for
Holy Anointing Oil given in Exodus 30:22-25.
The term sweet calamus was mistranslated
and put in place of Kaneh-Bosim
when King James of england commissioned a new translation (circa 1604-1611).
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Other nutritional concerns for Cancer Patients
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Foods to avoid to heal Cancer more effectively:
Red meat and refined sugars are a bad idea. If you have a sweet tooth, try to stay away from the white sugar and any sugars that have been through a lengthy refining process. Natural sugars such as honey or molasses and naturally occurring sugars in fruit are a good option. As I said in the introduction to this article, If you need more protein, I suggest eating raw shelled hemp seeds. Any vegetarian having trouble getting enough protein in their diet should buy some. A serving of 3 tablespoons packs 10 grams of protein!
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Red Meat
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A March 2012 study from Harvard School of Public Health (HSPH) researchers has found that red meat consumption is associated with an increased risk of total, cardiovascular, and cancer mortality. The results also showed that substituting other healthy protein sources, such as fish, poultry, nuts, and legumes, was associated with a lower risk of mortality.
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Refined Sugar
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n 1931, German biologist Otto Heinrich Warburg won a Nobel Prize for his research into the causes of cancer. In his studies, Warburg found that cancerous tumors fueled their growth through the metabolism of glucose — digested sugar. Although some scientists rejected Warburg’s theories for many decades, recent studies have drawn connections between different types of cancer and refined sugar intake.
Insulin Resistance and Cancer
The pancreas works with your digestive system to produce the hormone insulin, which aids in the metabolism of glucose. When you eat carbohydrates, the pancreas automatically releases insulin to help break the carbs down into glucose to fuel your cells. If you are insulin-resistant and eating a diet of primarily high-glycemic foods, your pancreas becomes overworked and cannot keep up with the demand for insulin, allowing glucose to build up in your bloodstream. Insulin resistance increases your risk of several diseases, including Type 2 diabetes, heart disease and some cancers. To prevent cancer, the World Cancer Research Fund and the American Institute for Cancer Research recommended against consuming sugary beverages and snacks in a 2007 report.
Research into Specific Cancers
Many later studies have shown a direct connection between insulin resistance, high-glycemic diets and certain types of cancer. In a study of more than 2,500 women published in the “Annals of Oncology” in 2001, the findings supported a connection between insulin resistance and breast cancer development. Another study published in the “American Journal of Epidemiology” in 2006 followed 16,000 Norwegian men for 27 years and found insulin resistance to be a predictor of prostate cancer. An analysis of a study conducted in Italy from 1986 to 1992 published in the “Annals of Oncology” in 2008 drew a link between high-glycemic diets and thyroid cancer risk.
http://www.livestrong.com/article/465680-refined-sugar-cancer/#ixzz2B0y79ySl
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endnote: a top-shelf bud asked me to create this excerpt from the FAQ’s about Phoenix Tears Therapy for the Beginner post. She makes the most beautiful hempwork necklaces. Here is a collage of pieces that I own created by the an artist from Ohio, Ms. Katarina Marie of Grateful Hemp
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Respectfully,
Breedheen O’Rilley Keefer
AKA Breezy Kiefair
links about breezy
blog
http://misshightimes.com/users/breezykiefair
on youtube
http://www.youtube.com/user/Mr8MrsKiefAir?feature=mhsn
art “like” page on FB
http://www.facebook.com/pages/The-Art-of-Breezy-Kiefair/154533251224064
fb profile
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@breezykiefair
the short 4 page version:
http://www.scribd.com/doc/64585079/My-Personal-Christmas-Present-to-the
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shine out from you, and plant the seed of peace in other spirits, for them
to cultivate.~{Remember… it is when we choose act on the issues that are in front of
our faces, when we choose to get involved instead of looking the other way
as our fellow man struggles, when we choose to take those small simple
little actions, working on righting little wrongs in our everyday lives that
really make change happen, those seemingly small actions are what really
make the world a better place and are a catalyst for greater social change.}
~Both quotes by Breedheen “Bree” O’Rilley Keefer~
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Related articles
- FAQ’s about Phoenix Tears Therapy for the Beginner (kiefair.com)
Questions?
send a pm through facebook to this profile
email: breezyorilley@gmail.com
snail mail:
Bréedhéen O’Rilley Keefer
P.O. Box 849
Franktown, Colorado 80116
Familial Mediterranean Fever ~ a Rare genetic disease
I do not look like I have a single drop of Mediterranean blood in me, so why do i care about this rare genetic disorder? Because the color of skin is only skin deep. Because despite the pale appearance of my exterior, I have the genetic ancestor from that part of the world who handed me this recessive trait. Because I have this disease and have to live with it…
I care because I need to repost the links as many times as possible in hopes that those related to me by blood will heed my warning and look for signs of the disorder in the kids…. I have made no secret of the fact that I am far estranged from my biological family, so I turn to electronic means to spread the word.
There is no cure, but the treatment does help….. There is no cure, but knowledge that there is indeed something wrong and that I am not a hypochondriac is soothing to the mind…. There is no cure, but it sure as hell does explain a lot about both myself and my blood relatives… BOTH my parents had to have the recessive gene in order for me to have this disorder. Both my parent’s sets of siblings may also be carriers of these recessive traits…. ALL of my blood siblings (half or full blooded) are POTENTIAL carriers of the defect…. Therefore, ALL of my blood nieces and nephews are potential victims of the disease as well as their children. It is my hope that those in my family will stumble upon this post and then value the family’s future generations enough to spread this information to where it may be of use (i emailed it directly to those whose email addresses I possess in my bloodline)
the below information was retrieved from: http://ghr.nlm.nih.gov/condition/familial-mediterranean-fever
What is familial Mediterranean fever?
Familial Mediterranean fever is an inherited condition characterized by recurrent episodes of painful inflammation in the abdomen, chest, or joints. These episodes are often accompanied by fever and sometimes a rash. The first episode usually occurs in childhood or the teenage years, but in some cases, the initial attack occurs much later in life. Typically, episodes last 12 to 72 hours and can vary in severity. The length of time between attacks is also variable. Without treatment to help prevent attacks and complications, a buildup of certain protein deposits (amyloidosis) in the body’s organs and tissues may occur, which can lead to kidney failure.
How common is familial Mediterranean fever?
Familial Mediterranean fever primarily affects populations originating in the Mediterranean region, particularly people of Armenian, Arabic, Turkish, and Jewish ancestry. The disorder affects from 1 in 250 people to 1 in 1,000 people in these populations. It is less common in other populations.
What genes are related to familial Mediterranean fever?
Mutations in the MEFV gene cause familial Mediterranean fever. The MEFV gene provides instructions for making a protein called pyrin (also known as marenostrin), which is found in white blood cells. This protein is involved in the immune system, helping to regulate the process of inflammation. Inflammation occurs when the immune system sends signaling molecules and white blood cells to a site of injury or disease to fight microbial invaders and facilitate tissue repair. When this has been accomplished, the body stops the inflammatory response to prevent damage to its own cells and tissues.
Mutations in the MEFV gene reduce the activity of the pyrin protein, which disrupts control of the inflammation process. An inappropriate or prolonged inflammatory response can result, usually accompanied by fever and pain in the abdomen, chest, or joints.
Normal variations in the SAA1 gene may modify the course of familial Mediterranean fever. Some evidence suggests that a particular version of the SAA1 gene (called the alpha variant) may increase the risk of amyloidosis among people with familial Mediterranean fever.
Read more about the MEFV and SAA1 genes.
How do people inherit familial Mediterranean fever?
Familial Mediterranean fever is almost always inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.
In rare cases, this condition appears to be inherited in an autosomal dominant pattern, in which one copy of the altered gene in each cell is sufficient to cause the disorder and affected individuals often inherit the mutation from one affected parent. However, there are other possible explanations of this apparent pattern. A gene mutation that occurs frequently in a population may result in a disorder with autosomal recessive inheritance appearing in multiple generations in a family, a pattern that mimics autosomal dominant inheritance. If one parent has familial Mediterranean fever (with two mutations in the MEFV gene) and the other parent is an unaffected carrier (with one mutation in the MEFV gene), it may appear as if the affected child inherited the disorder only from the affected parent. This appearance of autosomal dominant inheritance when the pattern is actually autosomal recessive is called pseudodominance.
Where can I find information about diagnosis or management of familial Mediterranean fever?
These resources address the diagnosis or management of familial Mediterranean fever and may include treatment providers.
- Gene Review: Familial Mediterranean Fever
- Gene Tests: Familial Mediterranean Fever
- MedlinePlus Encyclopedia: Familial Mediterranean fever
- MedlinePlus Encyclopedia: Secondary systemic amyloidosis
You might also find information on the diagnosis or management of familial Mediterranean fever inEducational resources and Patient support.
To locate a healthcare provider, see How can I find a genetics professional in my area? in the Handbook.
Where can I find additional information about familial Mediterranean fever?
You may find the following resources about familial Mediterranean fever helpful. These materials are written for the general public.
- MedlinePlus – Health information (3 links)
- Genetic and Rare Diseases Information Center
– Information about genetic conditions and rare diseases
- Additional NIH Resources – National Institutes of Health (2 links)
- Educational resources – Information pages (3 links)
- Patient support – For patients and families (2 links)
You may also be interested in these resources, which are designed for healthcare professionals and researchers.
- Gene Reviews
– Clinical summary
- Gene Tests
– DNA tests ordered by healthcare professionals
- ClinicalTrials.gov
– Linking patients to medical research
- PubMed
– Recent literature
- OMIM
– Genetic disorder catalog
What other names do people use for familial Mediterranean fever?
- Benign paroxysmal peritonitis
- Familial paroxysmal polyserositis
- FMF
- Hereditary Periodic Fever Syndromes
- Mediterranean Fever, Familial
- MEF
- Periodic Disease
- Periodic peritonitis
- Recurrent polyserositis
- Reimann periodic disease
- Siegal-Cattan-Mamou disease
- Wolff Periodic Disease
For more information about naming genetic conditions, see the Genetics Home Reference Condition Naming Guidelines and How are genetic conditions and genes named? in the Handbook.
What if I still have specific questions about familial Mediterranean fever?
Where can I find general information about genetic conditions?
The Handbook provides basic information about genetics in clear language.
- What does it mean if a disorder seems to run in my family?
- What are the different ways in which a genetic condition can be inherited?
- If a genetic disorder runs in my family, what are the chances that my children will have the condition?
- Why are some genetic conditions more common in particular ethnic groups?
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding familial Mediterranean fever?
amyloidosis ; autosomal ; autosomal dominant ; autosomal recessive ; benign ; carrier ; cell ; complication ;familial ; fever ; gene ; immune system ; inflammation ; inheritance ; injury ; joint ; kidney ; molecule ;mutation ; population ; protein ; pseudodominance ; recessive ; sign ; symptom ; syndrome ; teenage ;tissue ; white blood cells
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.
please also read:
http://emedicine.medscape.com/article/330284-overview#showall
Familial Mediterranean fever
Familial Mediterranean fever (FMF) is a hereditary inflammatory disorder[1]:149. FMF is an autoinflammatory disease caused by mutations in MEFV, a gene which encodes a 781–amino acid protein denoted pyrin.[2]
The disorder has been given various names including familial paroxysmal polyserositis, periodic peritonitis, recurrent polyserositis, benign paroxysmal peritonitis, periodic disease or periodic fever, Reimann periodic disease or Reimann’s syndrome, Siegal-Cattan-Mamou disease, and Wolff periodic disease.[3][4][5] Note that “periodic fever” can also refer to any of thePeriodic fever syndromes.
Epidemiology
FMF affects groups of people originating from around the Mediterranean Sea (hence its name). It is prominently present in the Armenian people, Sephardi Jews (and, to a much lesser extent, Ashkenazi Jews), Cypriots, Turks and Arabs.[6]
[edit]Signs and symptoms
[edit]Attacks
There are seven types of attacks. Ninety percent of all patients have their first attacks before they are 18 years old. All develop over 2–4 hours and last anywhere from 6 hours to 4 days. Most attacks involve fever.[6]
- Abdominal attacks, featuring abdominal pain, affect the whole abdomen with all signs of peritonitis (inflammation of abdominal lining), and acute abdominal pain likeappendicitis. They occur in 95% of all patients and may lead to unnecessary laparotomy. Incomplete attacks, with local tenderness and normal blood tests, have been reported.
- Joint attacks mainly occur in large joints, especially in the legs. Usually, only one joint is affected. Seventy-five percent of all FMF patients experience joint attacks.
- Chest attacks include pleuritis (inflammation of the pleura) and pericarditis (inflammation of the pericardium). Pleuritis occurs in 40% of patients, and makes it difficult to breathe or lie flat, but pericarditis is rare.
- Scrotal attacks due to inflammation of the tunica vaginalis occurs in up to 5% and may be mistaken for acute scrotum (i.e. testicular torsion).
- Myalgia (rare in isolation)
- Erysipeloid (a skin reaction on the legs, rare in isolation)
- Fever without any of the other symptoms listed above (25%)
[edit]Complications
AA-amyloidosis with renal failure is a complication and may develop without overt crises. AA amyloid protein is produced in very large quantities during attacks, and at a low rate between them, and accumulates mainly in the kidney, as well as the heart, spleen, gastrointestinal tract and thyroid.[6]
There appears to be an increase in the risk for developing particular vasculitis-related diseases (e.g. Henoch-Schönlein purpura), spondylarthropathy, prolonged arthritis of certain joints and protracted myalgia.[6]
[edit]Diagnosis
The diagnosis is clinically made on the basis of the history of typical attacks, especially in patients from the ethnic groups in which FMF is more highly prevalent. An acute phase response is present during attacks, with high C-reactive protein levels, an elevated white blood cell count and other markers of inflammation. In patients with a long history of attacks, monitoring the renal function is of importance in predicting chronic renal failure.[6]
A genetic test is also available to detect mutations in the MEFV gene. Sequencing of exons 2, 3, 5, and 10 of this gene detects an estimated 97% of all known mutations.[6]
A specific and highly sensitive test for FMF is the “Metaraminol Provocative Test (MPT),” whereby a single 10 mg infusion of Metaraminol is administered to the patient. A positive diagnosis is made if the patient presents with a typical, albeit milder, FMF attack within 48 hours. As MPT is more sensitive than specific, it does not identify all cases of FMF. Although a positive MPT can be very useful.[7][8]
[edit]Pathophysiology
Virtually all cases are due to a mutation in the MEFV gene on the sixteenth chromosome, which codes for a protein called pyrin or marenostrin. Various mutations of this gene lead to FMF, although some mutations cause a more severe picture than others. Mutations occur mainly in exons 2, 3, 5 and 10.[6]
The function of pyrin has not been completely elucidated, but it appears to be a suppressor of the activation of caspase 1, the enzyme that stimulates production of interleukin 1β, a cytokine central to the process of inflammation. In other words an ineffective pyrin doesn’t inhibit inflammation normally, resulting in inflammatory episodes of membranes at differing sites. It is not conclusively known what exactly sets off the attacks, and why overproduction of IL-1 would lead to particular symptoms in particular organs (e.g. joints or the peritoneal cavity).[6]
[edit]Genetics
The MEFV gene is located on the short arm of chromosome 16 (16p13). The disorder inherits in an autosomal recessive fashion. Therefore, two asymptomatic carrier parents have a 25% chance of a child with the disorder, a 50% chance of a child who is an asymptomatic carrier and a 25% chance of a child who does not carry the disorder. FMF patients who have children with a carrier or another FMF patient have a 50% and 100% chance, respectively, of having a child with FMF.[9][10]
There is one known case of an affected patient with only one parent who is a carrier. This is caused by a unique mutation on thesixteenth chromosome.
[edit]Treatment
Attacks are self-limiting, and require analgesia and NSAIDs (such as diclofenac).[6]
Colchicine, a drug otherwise mainly used in gout, decreases attack frequency in FMF patients. The exact way in which colchicine suppresses attacks is unclear. While this agent is not without side effects (such as abdominal pain and muscle pains), it may markedly improve quality of life in patients. The dosage is typically 1–2 mg a day. Development of amyloidosis is delayed with colchicine treatment. Interferon is being studied as a therapeutic modality.[6] Some advise discontinuation of colchicine before and during pregnancy, but the data are inconsistent, and others feel it is safe to take colchicine during pregnancy.[11]
Approximately 5-10% of FMF cases are resistant to colchicine therapy alone. In these cases, adding anakinra to the daily colchicine regimen has been successful.[12]
[edit]History
A New York allergist, Dr Sheppard Siegal, first described the attacks of peritonitis in 1945; he termed this “benign paroxysmal peritonitis”, as the disease course was essentially benign.[13] Dr Hobart Reimann, working in the American University in Beirut, described a more complete picture which he termed “periodic disease”.[14][15]
In 1972, colchicine was discovered to prevent attacks.[16]
The link to the MEFV gene was discovered in 1997 by two different groups, each working independently – the French FMF Consortium,[9] and the International FMF Consortium.[10]
[edit]See also
[edit]References
- ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews’ Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
- ^ Chae JJ, Wood G, Richard K et al. (September 2008). “The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment”. Blood 112 (5): 1794–1803. doi:10.1182/blood-2008-01-134932. PMC 2518886. PMID 18577712.
- ^ Dugdale III, David C; Jatin Vyas (2010-09-15). “Familial Mediterranean fever – PubMed Health”. PubMed Health. National Centre for Biotechnology Information. Retrieved 2011-04-24.
- ^ Enersen, Ole Daniel. “Whonamedit – Siegal-Cattan-Mamou syndrome”. Whonamedit? A dictionary of medical eponyms. Archived from the original on 2001-04-24. Retrieved 2011-04-24.
- ^ “Familial Mediterranean fever – Genetics Home Reference”. Genetics Home Reference. U.S. National Library of Medicine. 2011-04-14. Archived from the original on 2011-04-24. Retrieved 2011-04-24.
- ^ a b c d e f g h i j Livneh A, Langevitz P (2000). “Diagnostic and treatment concerns in familial Mediterranean fever”. Baillieres Best Pract Res Clin Rheumatol 14 (3): 477–498.doi:10.1053/berh.2000.0089. PMID 10985982.
- ^ Barakat MH, El-Khawad AO, Gumaa KA, El-Sobki NI, Fenech FF (1984). “Metaraminol provocative test: a specific diagnostic test for familial Mediterranean fever”. Lancet 1(8378): 656–7. PMID 6142351.
- ^ Huppertz HI, Michels H (1988). “[The metaraminol provocation test in the diagnosis of familial Mediterranean fever]”. Monatsschr Kinderheilkd 136 (5): 243–5. PMID 3405225.
- ^ a b The French FMF Consortium (1997). “A candidate gene for familial Mediterranean fever”. Nat. Genet. 17 (1): 25–31. doi:10.1038/ng0997-25. PMID 9288094.
- ^ a b The International FMF Consortium (1997). “Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever”. Cell 90(4): 797–807. doi:10.1016/S0092-8674(00)80539-5. PMID 9288758.
- ^ Michael O, Goldman RD, Koren G (August 2003). “Safety of colchicine therapy during pregnancy”. Can Fam Physician 49: 967–9. PMC 2214270. PMID 12943352.
- ^ Calligaris L, Marchetti F, Tommasini A, Ventura A (2008). “The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever”. European Journal of Pediatrics 167 (6): 695–696. doi:10.1007/s00431-007-0547-3. PMC 2292480. PMID 17588171.
- ^ Siegal S (1945). “Benign paroxysmal peritonitis”. Ann Intern Med 23 (2): 234–47. PMID 18124924.
- ^ Reiman HA (1948). “Periodic disease. Probable syndrome including periodic fever, benign paroxysmal peritonitis, cyclic neutropenia and intermittent arthralgia”. J Am Med Assoc 136 (4): 239–44. PMID 18920089.
- ^ synd/2503 at Who Named It?
- ^ Goldfinger, S.E. (1972-12-21). “Colchicine for familial Mediterranean fever”. New England Journal of Medicine 287 (25): 1302. doi:10.1056/NEJM197212212872514.PMID 4636899.
[edit]External links
- Proteopedia 2wl1 information about the MEFV gene.
- GeneReview/NIH/UW entry on Familial Mediterranean Fever
Breezy Says:
–Auto signature below–
Respectfully,
Breedheen O’Rilley Keefer
AKA Breezy Kiefair
links about breezy
blog
http://misshightimes.com/users/breezykiefair
on youtube
http://www.youtube.com/user/Mr8MrsKiefAir?feature=mhsn
art “like” page on FB
http://www.facebook.com/pages/The-Art-of-Breezy-Kiefair/154533251224064
fb profile
http://www.facebook.com/breezy.kiefair
@breezykiefair
the short 4 page version:
http://www.scribd.com/doc/64585079/My-Personal-Christmas-Present-to-the
shine out from you, and plant the seed of peace in other spirits, for them
to cultivate.~{Remember… it is when we choose act on the issues that are in front of
our faces, when we choose to get involved instead of looking the other way
as our fellow man struggles, when we choose to take those small simple
little actions, working on righting little wrongs in our everyday lives that
really make change happen, those seemingly small actions are what really
make the world a better place and are a catalyst for greater social change.}
~Both quotes by Breedheen “Bree” O’Rilley Keefer~
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Phoenix Tears Healing a Diabetic Ulcer (the healing begins)

Phoenix Tears aka Rick Simpson Oil aka Hash Oil
Before I begin this testimonial, Please take a few moments to acquaint yourself with Phoenix Tears.
Here is a video of how to make the oil. Please also visit the text tutorial here:
http://phoenixtears.ca/make-the-medicine/
for more information on this therapy, please visit the following links:
What It Does & How It Works
http://phoenixtears.ca/what-it-does-and-how-it-works/
excerpt from link:
If you are looking for a safe medication, look no further than what the hemp plant can provide. On top of all that it’s a medicine we can all grow and produce ourselves. Also there is no need for a doctor’s supervision with its use.
When the hemp plant is grown for medicinal use, you now have your own medical system that is much safer and effective than anything our current medical system provides. You still may require a doctor to set your broken leg, but you will no longer need the chemicals they have been pushing upon us.
Hemp is medicine for the masses and no one has the right to control its use. We are all different and we all have different tolerances for practically everything. So it is up to each and every one of us to determine for ourselves how much oil we require to maintain good health.
Over the years people have come to me who after years of treatment by the medical system did not even have a diagnosis for their conditions. But the oil exercised its amazing healing power and their medical problems were solved.
Another aspect of the use of hemp as medicine is its anti-aging properties. As we age, our vital organs deteriorate and of course this impairs the function of these organs.
Hemp oil rejuvenates vital organs even in small doses it is very common for people to report to me that they feel 20 to 30 years younger after only ingesting the oil for a short time.
Now let’s take it to the next level. What about people who ingest larger quantities of oil over a longer period of time like myself? After 9 years on the oil my body does not appear to be that of a 60 year old man. Instead, my body has the appearance of someone who is a great deal younger. When I have the oil at my disposal I like to take about a quarter of a gram a day. Of course, due to short supply, quite often I must go without so my own treatment has been erratic to say the least.
From my own experience with the oil I cannot help but wonder what would happen if a person was to ingest larger quantities of oil over a longer period of time. If a person were to do this, can they actually reverse the aging process and grow younger instead of aging.
From the oils effect on my own body by all appearances this seems to be the case. Someday soon when I have enough oil I intend to start taking a gram a day for a year to see what effect it has on my body.
Many people who have taken the oil have stated that they thought it to be the fountain of youth. From my own experiences with the oil I believe this to be true.
Please also see dosing information: http://phoenixtears.ca/dosage-information/
Please also see testimonials: http://phoenixtears.ca/testimonials/
Finally, Whose oil can you trust?
please also read: http://phoenixtears.ca/articles/whose-oil-can-you-trust/
*****Author’s note… the above information is my research source. It is how I learned about Phoenix Tears and why I wanted to try them… ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^
*****THE BELOW information is data gathered based on personal observation. I have utmost respect for Mr. Rick Simpson and his work, but I in no way have his permission or endorsement… just for honesty and clarity.
Fat Freddy has had a sore on his back for about 3 years and it would not heal! We started putting Rick Simpson Oil on it on November 23, then the next day we checked it and then checked it every 3 days afterwards, changing the oil and bandage every 3 days as well! Here is the progress so far! (WARNING THIS IS GRAPHIC!)
NOVEMBER 23, 2011 First treatment

November 23, 2011 9:32am fat freddy’s diabetic ulcer on his back before treatment of phoenix tears with 1984 penny for scale

November 23, 2011 9:32am fat freddy’s diabetic ulcer on his back application of first treatment of phoenix tears with 1984 penny for scale
November 24, 2011
We began to change the bandage every 3 days…
Please view this video of the continuing progress.
On December 9, 2011 this is how the wound looked….
*note* our supply of Phoenix Tears AKA Rick Simpson Oil AKA Hash oil ran out during the course of therapy. We substituted one treatment for Hemp-EaZe™ THERAPY CREAM. We have also been using the Hemp-EaZe™ for Baby & Me Spray to wipe away any excess oil when we change the bandage. Hemp-EaZe™ THERAPY CREAM is available here: http://tierrasolfarm.com/Hemp-EaZe-THERAPY-CREAM-333.htm Hemp-EaZe™ for Baby & Me Spray is available here: http://tierrasolfarm.com/Hemp-EaZe-for-Baby-Me-Spray-335.htm
In the future, I plan to do a blog post about my personal experience with the phoenix tears for my fibromyalgia and chronic fatigue syndrome. I doubt I will have any fantastic images, but I have already seen improvement since I have been ingesting this therapy.
For more information on getting Phoenix Tears
please call 678-362-3245
or email
thelasname@yahoo.com
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UPDATES BELOW!!!
A note before we begin…
You can also view all the relevant videos for this patient on this youtube playlist
And now…
The Healing Continues….
Fat Freddy‘s treatment began on November 23, 2011. We changed his bandage (covered with phoenix tears oil) every 3 days until around December 12, 2011.
Here is the progress from ! December 12, 2011 to December 26. 2011 (WARNING THIS IS GRAPHIC!)
We saw amazing progress. When the scab initially fell off in November, it left a pitted area from where the sore had been for so many years. In addition to healing over, this ugly pit began to fill in with pretty pink, healthy skin.
We began changing the bandage every 6 days as the healing proceeded.
December 30, 2011 to January 12, 2012
I did some additional research on diabetes and it’s effects on the skin.
According to WebMD, “Every 30 seconds, somewhere in the world, someone loses a lower limb as a result of diabetes”……
In my opinion, nearly all of those amputations could be prevented if we would stop running from the cure for so many diseases & start using Rick Simpson‘s Run From The Cure method to make Hemp oil.
(link to reference article from WebMD http://diabetes.webmd.com/features/diabetes-wounds-caring-sores)
I did not realize how many DIFFERENT ways Diabetes affects the skin! I’m so glad that I know about the many diseases that are treated and cured with Rick Simpson oil…. There is a cure for Cancer, but it is not FDA approved. Phoenix Tears work! (and diabetes, and Fibromyalgia, and Autism, and so much more!!!)
the below link details the many ways that diabetes affects the skin
http://telemedicine.org/dm/dmupdate.htm#bp
for more info on phoenix tears, please visit: http://phoenixtears.ca/
For more info on “Fat Freddy” of the Freak Brother’s Comics (a longtime cannabis freedom fighter and the dude whose back we are healing) please visit: http://www.fatfreddy.com/
to buy Hemp EaZe Baby & Me Spray (the non thc lotion I have been using along with the PTO) please visit:
http://tierrasolfarm.com/Hemp-EaZe-for-Baby-Me- Spray-335.htm
need to know more? btokeefer@gmail.com
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April 1, 2012 Update… No April Fool’s joke here!
4/1/2012 Updated image of the healing.
Around one edge, some light scaling of skin remains. The scar itself continues to fill in where it had been an sunken area on the back. We are continuing to change the bandage about once a week. Have a blessed day. We will continue to update this post as we can. The authoress of the post is currently nursing a broken pelvis.
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April 11, 2012
We changed the bandage this morning, lo and behold, all the scaling has gone! We are now continuing treatment only as scar reduction! It has been so amazing to watch this horrible wound heal up and begin to disappear. Here are the latest pics.
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April 20, 2012 to May 5, 2012 UPDATE
There seemed to have been a deeper infection going on. We continued therapy for scar reductive therapy. Now we have entered a second phase of deeper healing. We’re calling it the “Dave Triplett effect”
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for more information please also see:
Cured: A Cannabis Story (A Film By David Triplett)
Cannabis cured my skin cancer. This is my story.
It has been proven that concentrated cannabis extract oil cures cancer.
Why hasn’t The U.S. National Cancer Institute or The American Cancer Society tested Cannabis Oil?. Is it lack of personnel (2,100 USNCI staff members) or limited financial support (USNCI 2010 budget of $5.1 Billion dollars!)
Cannabis Concentrate or extract is the same as Rick Simpson’s “Hemp Oil”. Hemp seed oil is NOT what Rick Simpson is making and using.
Google “cannabinoids” and “cancer”.
Google “endocannabinoids” and “cancer”
Google “THC” and “Cancer”.
Google pubmed, go there and look up “endocannabinoids” and “cancer”, as well as “cannabinoids” and “cancer”.
Google Dr. Robert Dr Robert Melamede and cancer”.
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May 12 -18 2012 UPDATE
http://www.youtube.com/watch?v=4LMr4tFAhSI
Update of the healing of fat Freddy’s back with Rick Simpson’s Phoenix Tears Method applied topically to the skin.
view all the relevant videos in this play-list: http://www.youtube.com/playlist?list=PLB7A05ED23E5AE962
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For more information on getting Phoenix Tears
please call 678-362-3245
or email
thelasname@yahoo.com (tell him Breezy’s Words Sent you)