Category Archives: medibles
MEDICAL MARIJUANA: MISCONCEPTIONS ABOUT ALTERNATIVE MEDICINE
MEDICAL MARIJUANA: MISCONCEPTIONS ABOUT ALTERNATIVE MEDICINE
BY: Natalie Gray
Medical marijuana or MMJ has been used for decades now to help people afflicted with serious medical conditions that include, but are not limited to glaucoma, cancer, epilepsy, AIDS, and MS (Multiple Sclerosis). As one of the most effective agents that help people cope with chronic pain, medical marijuana offers patients relief from extreme discomfort by alleviating their symptoms.
Understanding the Science Behind Medical Marijuana
Understanding the science behind the effectiveness of marijuana is important in order to dispel these myths and make a well-informed choice about what it truly offers. When administered under the supervision of a qualified and competent doctor or medical practitioner, medical marijuana reduces the pain and nausea that various health problems cause. Scores of people believe that medical marijuana is extremely addictive, and it increases the dependency on the drug.
Research indicates that there is no evidence to support this belief because to start with, medical cannabis does not even have any chemicals that may trigger addiction in people who use it as a part of their treatment process. Then there are other misconceptions that MMJ may also lead to the use of hard drugs such as cocaine and like the former, this is also just a misconception. While medical marijuana can be smoked like a regular banana kush, this is not the only way that it can be used.
There are mainly two types of cannabinoid receptors; CB1 and CB2 that trigger a cascade of biological events within them. While the former type is mainly found in the nerve cells of the brain and is responsible for the mind altering effects of cannabis, the latter is found all over the body and it could be the prime suspect that triggers the biological effects of these cannabinoids on the other parts of the body apart from the brain. So, designing suitable drugs based on the active ingredients that are found in hash oil may be important for the treatment of cancer.
Medical Marijuana As Alternative Medicine
Right from prescription drugs and pills that contain synthetic forms of medical marijuana to other alternate treatment methods, cannabinoids such as THC can be delivered to the body without smoking MMJ. The marijuna seeds, flowers and leaves can be soaked in a mixture of alcohol to extract the cannabinoids in marijuana. This infusion can either be added to drinks and food or absorbed through skin patches and in this form; it takes MMJ as little as a half hour to produce the desired effect. The active components can also be transferred into cooking oil and butter by simmering the plant in them for several hours. This is usually used to bake cookies and brownies or make other types of food that a patient might find appetizing.
Thought there are tests that show that Medical cannabis can cause short term memory loss in some patients who are undergoing treatment, the truth is that the effect is only temporary. Medical marijuana neither reduces their intelligence nor does it affect their long-term memory. Though medical cannabis is an all-natural substance that is obtained from plants, the misconceptions about it are quite controversial and baseless.
Medical Marijuana Works at A Fundamental Level
It is amazing that smoking cannabis works so much better than many pharmaceuticals, which are always absorbed through the proper medium. By setting a plant on fire, inhaling the resulting smoke, and blowing it out, much more relief can be found than ingesting a pharmaceutical substance that decades of research was put into.
The fact that smoking cannabis works better than pharmaceuticals is a testament to its place as humanity’s greatest medicine, but what really matters are the effects people have been having with extract medicine. There is an entire movement working to spread the truth that extracts are capable of curing/eliminating or completely controlling serious diseases like cancer, heart disease, arthritis, Crohn’s, chronic pain, IBS, hepatitis C, multiple sclerosis, Parkinson’s, mental disorders, and more.
Cannabis works against so many conditions because it functions at a fundamental level, restoring balance to all body systems. Since all disease is an imbalance of some kind, cannabis is the best herb for restoring balance.
Bottom Line
Cannabis is one of the most medicinal plants in the world, and when prepared into extracts, its true power is released. The main problem with the medicinal cannabis movement at this point in time is its focus on smoking marijuana, or even vaporizing it. The bottom line is that’s not the right way to use cannabis as a medicine, as effective as even that can be., and its effects greatly exceed what smoked marijuana could ever achieve. Medicine is not intended to be absorbed in a low concentration through the lungs, it is supposed to go through the digestive system in a highly concentrated form.
Natalie Gray is a Biochemical Engineer. She works in the Research and Development team that focuses on the design and construction of unit processes. She is a recreational marijuana supporter and her love for organic chemistry brought her to medical cannabis. She grows her own flowers, working on different projects and study everything above and under cannabis roots.
For more awareness and news follow me @
https://www.facebook.com/profile.php?id=100033069654281
Protect Colorado Springs Home Grows
Protect Colorado Springs Home Grows by: Audrey Hatfield
How many registered cannabis patients do you think live in Colorado? How many refugees have given up their former lives to pack up and move here for access to medical cannabis? How many people in general utilize cannabis in some form or another in our state? There are approximately 108,000 registered cannabis patients and out of that many, how many of you have a clue as to what is happening in some city’s across Colorado regarding your rights as a cannabis patient? Very few.
Back in 2012 when the Amendment 64 campaign was rearing its ugly head, I was against it for several reasons. Not because I’m a selfish bitch that didn’t think everyone deserves access to cannabis, it was because, it was and is, a garbage piece of legislative prohibition, designed to benefit our government in the form of higher tax dollars, in disguise as “legalization.” We were all assured by 64 supporters that “medical would not be affected.” A64 was nothing but “legal lies” and too many people lapped it up as “progression” and “baby steps” towards “legalization.” “Regulation works,” “Regulate like alcohol.” Bullshit, all of it, as predicted!
Let’s forget about Amendment 64 for a minute and before you chastise me for using the term “medical cannabis,” there is a difference. That difference is, Amendment 20 and those of us that rely on cannabis as our medicine. For us, it’s not about just “getting high.” And no, I don’t have anything against anyone that does. Cannabis should be available to us all, but not this way. Not thru Amendment 64.
Right now, right under your noses we are slowly being made criminals once again. The MED is “recommending” to all jurisdictions to limit plant counts. One by one, city by city, slowly, Amendment 20 is being blown off by Colorado government officials, in part because of the fact that we have rec and rec generates more tax funds. You might think that it doesn’t matter because we “have A64”. But it does.
In a recent article in local paper the “Gazette Telegraph,” Colorado Springs City Council proposed ordinance 16-52, on May 10, that was signed by Mayor John Suthers, just a few days after on May 13.
In a nut shell, this ordinance (above,) is making it criminal to grow more than 12 plants per household without regard to the fact of ones plant count recommendation (Read above links). Yes, you heard it, it will be CRIMINAL! You will be a CRIMINAL, for exercising your rights under Amendment 20. Pay attention to what this will mean for patients here and eventually in the entire state.
https://coloradosprings.gov/sites/default/files/051016_personal_cultivation_ordinance_16-52.pdf
Colorado Springs is a home rule municipality and basically what that means, is they can make their own rules. HOWEVER, when it comes to this situation they can not decide how many plants a patient is allowed to have! What the fuck? Why is this happening? Amendment 64. Why isn’t it being stopped? Greed and ignorance.
All patients with higher plant counts will be affected, however, the patients that will be hurt the most are some of the many children whose parents moved here to treat their childrens rare illnesses with cannabis. Two of the families that will be affected and turned into criminals if arrested, will be Moms, Rebecca Lockwood and Marisa Kiser. Because of their childrens high plant counts and the negative impact it would have on their childrens health, Rebecca and Marisa, sprung into action. They decided to set up a meeting with City Council to get some answers and find compassion for all patients and spear headed an email campaign to Springs City Council.
Rebecca fears for the health and well-being of her child Calvin, as he has a plant count of 73 to treat his femoral retroversion, a debilitating abnormality, affecting the lower extremities.
http://www.aafp.org/afp/2003/0801/p461.htmlhttps://www.youtube.com/watch?v=T8OYxQq7mIE Marisa Kisers son Ezra, just turned 4 and went in hospice when he was just 3. He suffers from violent seizures and at one time, had an unexplained onset of dystonia so severe that he broke 8 bones in one year. He has a 72 plant count. These are just 2 of the families that will be affected by this bullshit.
It was in a May 31 meeting that the Moms were told by the council members in attendance that, “The limited plants counts are just the beginning, a ban will be placed on all home grows, not just here, but thru out the state.” This very phrase was confirmed the beginning of June from council members in a separate meeting between members of council and member Bridget Serrit, of the newly formed organization, Colorado Patient Rights Coalition
108 million patients and only a handful of you are or have been getting involved with the blatant disregard of our rights. This is going to affect you! Understand what it means! Get off of your asses and stand up for yourselves or bow down to your rights being stepped on by our local politicians. We all need to come together in force and show them that this will not be tolerated! Coming together in numbers will have greater impact and that is what it will take. This WILL happen in your town next, you need to be aware and know your rights as a patient.
Whether you grow or not, what can you do? First, research and familiarize yourselves with Amendment 20 and any laws regarding medical access in Colorado. Send emails to your local government officials that are implementing these laws. Call and leave them a brief, yet detailed message. Stand up for your rights! If you are available during the day, attend any protest about the matter that you see being advertised. Protests are being set up right now in Colorado Springs in front of Mayor Suthers office in Colorado Springs, on a monthly basis. The organization also has started a petition that as patients, you should sign.
https://www.facebook.com/events/266481020371172/https://www.change.org/p/colorado-state-house-keep-it-legal-colorado If you have paperwork to support your plant count recommendation, continue to grow that plant count. If police come to your home, DO NOT, under any circumstances, allow them access inside your home without a search warrant. DO NOT speak to the police. Record audio if they are in your home or at your door. DO NOT be swayed by the scare tactics they will try to use to get you to take a plea deal if you are arrested. You can and will win your case! It has been done! Now more than ever, is the time to get involved! Strength in numbers! Stand up!
http://www.westword.com/news/medical-marijuana-patient-bob-crouse-acquitted-another-wasteful-prosecution-5859198http://www.dailycamera.com/boulder-county-news/ci_16965794
http://gazette.com/jury-returns-not-guilty-verdict-in-mmj-case/article/140056Audrey Hatfield
Former Founder and President of C4CPR
Medical Cannabis Patient and Colorado Activist
Write to city council allcouncil@springsgov.com
Questions?
send a pm through facebook to this profile
email: breezyorilley@gmail.com
snail mail:
Bréedhéen O’Rilley Keefer
P.O. Box 849
Franktown, Colorado 80116
5 years of spreading KiefAir
Kiefair.com is 5 years old today
in its present incarnation, 7 years old if you count the time it was breedheenorilleykeefer.com
Each step along our individual paths changes us. Some experiences grow body, mind, and soul. Other experiences cause those same parts of us to shrink and ache endlessly. The trick is to let each step teach you even if it pains you. When you dedicate yourself to a task with little hope of recognition or monetary gain, many steps on the path are painful. No matter how much you give or how many you touch, there are still more in need. We live in a harsh world. My hat/cancer bandana off to anyone on the path to healing themselves and/or helping a loved one get relief in the most natural way possible. It takes a lot of courage and resolve to reach the end of the modern medicine road and only be left with options you may be logically against (such as chemo). It’s just as difficult to dutifully stand by and genuinely unconditionally love someone whose body is in decline.
As difficult as those decisions are, being public about them makes those choices even harder, but the stories we tell and leave behind in this time when cannabis legality is in its infancy of revival are a testament to the plant, it healing and transformative powers, and the lives of those left searching for comfort when modern medicine can’t offer it. Each of us who has chosen to tell our tale in the public forum of our day (the internet, or public eye in general) is living history. My endless gratitude to all those out there playing nurse to a loved one so limited in physical ability. Watching the cannabis world work to change from prohibition to test markets for medical use to states defying the federal government to decriminalize for adult use has been a heart twisting journey every step of the road. Please don’t forget the chronically ill folks and their caregivers for each recreational bowl you enjoy or sell legally. We still have a long way to go to honor the people who put their entire lives and health on the line in order to create change. Let’s begin by more and more programs to help the low income patients among us.
After many years of dedication to the cause of cannabis education and healing, This is the greatest need I see in the movement today: Just too many folks with too little resources and too much pain while the price of cannabis remains a burden to their largely ssi/ssd funded existences while pounds of useable cannabis are grown in the name of someone suffering and sold elsewhere by their “caregiver” for a profit. We must do better by the low income legal cannabis patient if we ever hope to legalize cannabis for medicinal or recreational use across the board. But as an individual, I can only offer individual mercy. Lately I’ve been giving free oil to individuals legal in Colorado and to cannabis charities such as Greenfaith Ministries. We need to see more of this kind of mercy.
The Greenfaith community supports a wide range of outreach programs, including:
- low income oil program* #fuckcancer #cannabiskillscancer
- cannabis sacrament for church members and the financially challenged*
- food donations to shelters, families, and the homeless*
- cannabis awareness events and presentations
*At this time, these programs are available only to members in Colorado
Feel free to wander around Kiefair.com, wish the site a happy anniversary, comment on and share your favorite articles from years past. Also feel free to comment on this post for any improvements or changes you would like to see to the site. Moving forward, I have a project to preserve samples of products I make and products available in the market for future research. I imagine a time when we are looking back at this period in our shared history as the dawn of cannabis legalization. I imagine scientists wanting to know exactly what we were using. To preserve this history, the best, the good, the bad, and the ugly, I have procured slides and lab vials to make samples to carry on after us.
My next article covers making your own massage oils. As a preview for those eagerly awaiting the write up on that article, Let us have a look at the history of extracting healing compounds or scent compounds from various plants. This history is essential to understanding the next article from kiefair.com
History of Essential oil extraction and perfumery
I invite you to come and visit the site through a sampling of the most read articles. Scroll below the photo for the top read articles according to my site’s stats, 2014 reading statistics. Let’s take a look at what people are reading.
Now, some Honorable mentions.
Green Living in a Red State and Talking to Your Doctor, Support from Social Media, and Living Green in a Red State Part by Verde LoneOwl
DIY Cannabis Cure oil healing: The tale of Wren by Wren SmilingDeer, lady of the wood
The tale of one of many who has taken information they learned on kiefair.com and had the courage to use that knowledge to treat their own illnesses with it.
Hipgnotist’s High Crimes and Hi-jinks
Tolkien was a stoner… Was Lembas Bread made of Hemp Seed?
This post is not to debate with others about if J.R.R. Tolkien was a stoner or not. This post is for people who have already determined for themselves that he did like to suck on a weed pipe every now and again and who wonder about what is really in Lembas Bread.
Duke the Cancer fighting Dog and RIP Duke
A dog who teaches us that not every case is a clear success, but not every gift is wasted… we lost duke but ended up helping his owner.
Naphtha is not good for you!
Certainly one of our most controversial posts. Just check out the associated youtube commentary.
Phoenix Tears Healing a Diabetic Ulcer (the healing begins)
And Phoenix Tears Healing a Diabetic Ulcer (updated Journey)
Fat Freddy has had a sore on his back for about 3 years and it would not heal! We started putting Rick Simpson Oil on it on November 23, 2011 then the next day we checked it and then checked it every 3 days afterwards, changing the oil and bandage every 3 days as well! I documented the process as long as I was the live in maid/nurse for the patient. (WARNING THIS IS GRAPHIC!)
Familial Mediterranean Fever ~ a Rare genetic disease
I do not look like I have a single drop of Mediterranean blood in me, so why do i care about this rare genetic disorder? Because the color of skin is only skin deep. Because despite the pale appearance of my exterior, I have the genetic ancestor from that part of the world who handed me this recessive trait. Because I have this disease and have to live with it…
Now, The Top 10 Most Read Posts
10. Hannah Hurnard’s “Hind’s Feet on High Places” audiobook video series
I was rather surprised this one made the countdown because the video series is as yet unfinished.
playlist on youtube: http://www.youtube.com/playlist?list=PLwc43UiVjiudD0DhoUELBfeHOamG_Hvtj
A set of videos in Tribute to the writing of Hannah Hurnard, “Hind’s Feet on High Places” to Art of Breezy Kiefair i just put music and art to a book that has been a favorite since childhood… my mother used to read me that book…. call it a tribute to her and an introduction of the book to an audience that may otherwise remain unaware of it. I recommend it for anyone with anxiety or PTSD
9. Remembering Westley Thorin Keaton Roberts, a child murdered… his murderer acquitted
This is the tale of how I lost my only child and had to watch the individual who logically was guilty walk free. I was rather surprised it made the most read articles list. May Westley’s love and story live on. My maternal heart will never stop longing for what should have been.
8. Dixie Elixirs, Dixie Script, Dixie Dewdrops and The Clinic Colorado Review
7. Cannabis Oil Advocate Ronnie Smith Suddenly Dies from Leukemia
Please also read: Cannabis Activist Roland a Duby’s Censored Wikipedia Article
Ronnie Lee Smith, aka Roland A Duby made much of Kiefair.com possible. In April 2014, he lost his battle with Leukemia after being falsely imprisoned by Yavapai county in Arizona. We got Ronnie out of jail, but only in time for him to die with a pipe in his hands. While Ronnie was alive, he tasked me to keep his oil making method alive. I have done my best to ensure I keep this task entrusted to me by making his method freely available to anyone willing to learn.
6. A few words on the properties of Isopropyl alcohol
5. Cannabis products and Colorado Dispensary Reviews
*****Note, I have not updated the review page in quite some time. Some of the dispensaries I have reviewed may no longer be in business. The quality at the locations I have reviewed may have changed due to a change in ownership, grower or extraction agreements. Nearly all of my reviews are of MEDICAL locations, so please check to see if they have a retail location before using any of these reviews for a vacation guide.
4. How to make Cannabis Cure Oil without alerting the neighbors
3. Hemp Seed and Hemp Seed Oil ~ a superfood, but not a cancer cure
2. How to Extract Cannabis Cure Oil with alcohol (Phoenix Tears)
1. FAQ’s about Phoenix Tears Therapy for the Beginner
Here’s to another Great Year!
Grateful Dead Throwing Stones
Check out our videos on Youtube
Do you use Kiefair.com? Do you support me giving out info on cannabis oil creation for free? Do you support my free oil program with the colorado cannabis charity known as Greenfaith Ministry? Well, you may be unaware that one little lady pays for all costs associated with KiefAir.com. The way the site stays afloat with its mini library of cannabis related reference information is through sales of art and books. Each year, I must make $300 in PROFITS from the art at my etsy store and my poetry book sales on amazon.com.
Have a look at some samples from my portfolio, all of these images may be purchased to support kiefair.com
Please remember I only make pennies per art print I sell, so I need to sell a lot of pieces each year. I was very worried about keeping the site open for 2015. The holiday season left me with not one sale. But People pulled together, and We are all set to keep the site open through February 2016!
This is the tale of how I kept the site open this time… previous years, the money had come from my medication budget. This year was different… this happened because a long time patron gifted me $100 to bring the hosting fee bar a little lower, but he was a special case, my first patron ever who seems to still want to pay more for some ceramic figures I did when I was about 14. He always sends me some cash during the winter holidays and on my birthday. In truth this anonymous donor has been more of a father to me than my own. One of the few positive male role models i have had in mu life. The rule is to spend it on something for myself. I misbehaved this year and give the gift to you. This year I’m put it towards continuing to give the gift of information via kiefair.com . Pebbles Trippet, a prominent writer for Skunk Magazine bought a clutch of 4×6 limited edition Maya Angelou memorial prints. Other patrons got posters or 8×10 prints and we made our goal to keep the site open! My thanks to all Patrons!
Each year, I allow you, the reader/viewer to decide if kiefair.com stays alive. If I get sales, all profit (save my usual tithe if 10% of all profits) will go to saving KiefAir.com. I hope we can do better on those sales and keep the site alive. Remember the power is yours to make it live or let the library die. Any image from my please bogart my art page is for sale except the maya portrait.
This shop accepts Etsy Gift Cards.
2. Complete your transaction here and let the artist know what image you desire. Ms. Breezy will ship you a print in the size you desire right away!
- Canna Fairy Print
-
$11.00USD
- Joshua’s Wish
-
$11.00USD
- Puurrrfectly High Print
-
$11.00USD
- Good morning! Seen through Green shades
-
$11.00USD
Other Products:
Try it free
|
||
Of Pain, Poetry and Pot [Kindle Edition]
|
|
Book Description
Product Details
|
Customer Reviews
6 Reviews
|
Average Customer Review
Share your thoughts with other customers
|
Most Helpful First | Newest First
|
4 of 4 people found the following review helpful
5.0 out of 5 stars Rare and Lovely, October 2, 2013
By
Verified Purchase(What’s this?)
This review is from: Of Pain, Poetry and Pot (Kindle Edition)
Would You Like To Pick Breezy’s Brain? This wonderful book is a chance to witness the creative process at work; author Breezy Kiefair (aka Breedheen O’Rilley) is the real deal, a gifted poet/journalist/activist on the forefront of the battle for medical marijuana patients’ rights and for truth in media. And speaking of truth, emotional truth is exactly what you’ll get here. Breezy isn’t afraid to take an open-eyed, unsparing look at society, at herself, at her illnesses, at the lies we tell ourselves and each other — and at the scintillating, breathtaking beauty which is more real and more powerful than all else. Highly recommended.
3 of 3 people found the following review helpful
5.0 out of 5 stars Beautiful., January 14, 2014
This review is from: Of Pain, Poetry and Pot (Kindle Edition)
Written by someone very intimate with pain on many different levels. Beautiful and honest. I can’t wait to find out more about this amazing young woman. I originally borrowed this book. I have now read it twice and I have to own it. It must become a part of my permanent collection, along with anything else I can find which flows from this beautiful author.
3 of 3 people found the following review helpful
5.0 out of 5 stars Passion and creativity fills these pages, December 27, 2013
By
jusamy2002 “jusamy2002″ (Dallas) – See all my reviews
Verified Purchase(What’s this?)
This review is from: Of Pain, Poetry and Pot (Kindle Edition)
The poems and rhythm that comes from the author’s feelings show you that she uses her medical cannabis passion and even frustrations to put her concerns into words we can understand. You can feel her pain – you can feel her pride. The transposed songs were a great touch.
3 of 3 people found the following review helpful
5.0 out of 5 stars Talented, insightful artist and writer,November 25, 2013
By
Verified Purchase(What’s this?)
This review is from: Of Pain, Poetry and Pot (Paperback)
This multi-talented artist and writer amazed me with her insightful and sometimes heartbreaking poetry. Her artwork is not only beautiful, but different from any I have seen. I have actually ordered several individual prints off her website to give as gifts this Christmas. I highly recommend this book.
2 of 2 people found the following review helpful
5.0 out of 5 stars Fabulous, February 8, 2014
Verified Purchase(What’s this?)
This review is from: Of Pain, Poetry and Pot (Kindle Edition)
As an activist,a woman and a HUMAN BEING,, I could feel the pain in Ms. O’Rilley’s poetry. Yet I could also feel the triumph. A must for all “pot’ lovers, I got it for 2.99 for my Kindle and it was MORE than worth it. I’ve read these poems over and over, you will too.
1 of 1 people found the following review helpful
5.0 out of 5 stars Of Pain, Poetry and Pot, March 13, 2014
This review is from: Of Pain, Poetry and Pot (Kindle Edition)
This is an excellent book written by a very gifted, unique woman Breezy Keifair. I loved the whole book and have read it a couple of times so far. She is an artist that does her work under the influence of pot for the pain she is in and you can feel that pain with her words. I could really relate to that and a lot of other things in the book. I highly recommend this book. She is also a very gifted artist besides being a good poet and writer.
|
Questions?
send a pm through facebook to this profile
email: breezyorilley@gmail.com
snail mail:
Bréedhéen O’Rilley Keefer
P.O. Box 849
Franktown, Colorado 80116
MarQaha soda, and Cannabis Xtract Capsules purchased at JP Wellness
MarQaha soda, and Cannabis Xtract Capsules purchased at JP Wellness 7 Of 10 Medicinal Leaves
MarQaHa Soda, and Cannabis Xtract Capsules purchased at JP Wellness
I sampled the Orange Crush Creamsicle flavor from their higher potency Inkblot line of drinks. I like mine on ice cut with seven up. Reminds me of squirt soda or sparkling grapefruit juice. I give this a 7 of 10 Medicinal Leaves.
Nutrition facts:
10mg THC (approx one dose)
12 oz bottle-servings 11
Calories 75
approx 110mg THC per bottle
Ingredients: filtered water, organic white grape juice, organic orange juice concentrate, organic vanilla extract, organic agave nectar, cannabis, natural flavors, gum acacia, sunshine
Some thoughts posted during the review
from their website:
Here are just a few of the amazing flavors available:
Caffeine Free:
• Lemon-Aid
• Pomegranate
• Hibiscus Tea
Small amount of naturally occurring caffeine:
• Mint Green Tea
• Yerba-Mate
Why use marQaha’s drinks, because they are REAL medicine!
More than just a beverage we take pride in bringing you an all-natural organic, great tasting alternative for your medicine. When comparing our drinks to others in the marketplace here are some things to keep in mind:
• We use organic real ingredients
• Never High Fructose Corn Syrup!
• Properly dosed every time using HPLC equipment.
• Tens of thousands of satisfied patients
Does your drink tell you how much medicine you are buying?
We could make a cheaper drink using less medicine and synthetic ingredients but we wanted to create the best drink possible for our patients.
Freshly Brewed and Finely Tuned in the State of Colorado
~~~~~~~~
Cannabis Xtract Capsule 0 of 10 Medicinal leaves
While these capsules advertise a higher thc content than the pills I reviewed from Dixie Elixirs, I found zero medicinal value from this preparation
http://www.cwdmeds.com/portfolio/capsules
from their website:
Cannabis Capsules
200 mg 2-pack (100 mg/capsule)
100 mg 2-pack (50 mg/capsule)
Designed for patients with a high tolerance, and chronic pain or illness. These capsules offer patients a smokeless alternative with a potent dose.
This product is infused with medical marijuana and was produced without regulatory oversight for health, safety or efficacy and there may be health risks associated with the consumption of the product.
FOR LICENSED MEDICAL MARIJUANA PATIENTS ONLY
Levels of active components of medical marijuana reported on product labels are not subject to independent verification and may differ from actual levels.
KEEP OUT OF THE REACH OF CHILDREN!
want to compare these products with similar brands? click here
More Northern Lights From JP Wellness
10 of 10 leaves
A previous video on Northern Lights from JP Wellness
Related articles
Dixie Elixirs, Dixie Script, Dixie Dewdrops and The Clinic Colorado Review
Dixie Elixirs medible company:
http://dixieelixirs.com/products/dixie-elixirs/
6701 E. Stapleton Drive North
Denver, Co 80216
1-866-928-1623
and
The Clinic Colorado
http://www.thecliniccolorado.com/locations/the-clinic-colorado
3888 E Mexico Ave
Denver, Co
(303) 758-9114
colorado@thecliniccolorado.com
Some Images of the Dixie Line of Products and other items
All Purchased at THE CLINIC COLORADO
Images of December Weed Reviews coming soon to kiefair.com
Impressions of the Dixie Line of Products:
Dixie Elixirs overall 6 of 10 Medical Leaves
The Dixie Elixirs are pleasantly tasting and on par in potency with products such as Keef Cola that I have tried before. I must say that another soda brand I reviewed at the same time, Marqhaha (Orange Crush Creamsicle flavor) packed more medicine on the label and more medicinal effects than any of the flavors of Dixie Elixirs that I tried (Old Fashioned Sarsaparilla, Sparkling Blueberry, and Sparkling Mandarin). I would also like to add that there is a slight aftertaste that is artificial that isn’t extreme but is a little unpleasant to me. The initial flavor of each drink was very nice and married well with the hash flavor. Overall impression of the soda? It likely is very marketable to the recreational community that does not expect so much potency from a product. I think there are many who will want to drink this and be seen drinking this, but it just does not have enough medicine in it for a patient like me. 6 of 10 medical leaves. serving size 12 fluid ounces, calories 160, Carbohydrate (from sugar) 40g
Old Fashioned Sarsaparilla (my favorite of the flavors)
Dixie Elixirs Old-Fashioned Sarsaparilla. So far it is the tastiest of all the colas I have been trying. The flavor marries well with the hash and it is really pleasant to drink. Still something artificial in the aftertaste (and listed on the label.).
Ingredients: Carbonated filtered water, sugar, citric acid, natural and artificial flavor, caramel color, THC oil 100mg
Sparkling Blueberry
The blueberry soda is pleasant. Still got that artificial aftertaste I’m not digging from this company….But again the taste is relatively pleasant. Hash can be tasted and marries fairly well with the blueberry flavor.
Ingredients: Carbonated filtered water, sugar, citric acid, natural and artificial flavor, red 40, blue 1, THC oil 100mg
Sparkling Mandarin
Most aftertaste of the group.
Ingredients: Carbonated filtered water, sugar, citric acid, natural and artificial flavor, glycerol ester of wood rosin, yellow 6, red 40, THC oil 100mg
Dixie Scripts overall 6 of 10 medicinal leaves
These capsules are likely a godsend for someone who has a low tolerance level. For someone who takes a lot of cannabis in a lot of forms, they just seem to lack potency. I found myself reaching for my phoenix tears hash oil to fill the pain gap.
Dixie Scripts AM Focus:
Product Description from Package:
Extraordinarily Concentrated cannabis extract capsules with a natural uptake agent
*approx. 50mg of active THC per capsule.
Included THC and the herbs aswagandha and eleuthero (known for their energizing properties) providing patients with a stimulating sensation and increased focus, for early daytime use without any side effects.
Information on Aswagandha herb
Information on Eleuthero
Dixie Scripts P.M. Sleep
Product Description from Package:
Extraordinarily Concentrated cannabis extract capsules with a natural uptake agent
*approx. 50mg of active THC per capsule.
Contains Theanine and hops along with natural Cannabis to reduce physical and mental stress and promote relaxation. This is a wonderful option for patients with night time pain and trouble falling asleep.
Information on Theanine
Information on Hops
Dixie Scripts Concentrated Hemp CBD Capsules
Product Description from Package:
Dosage: One to two capsules to provide. fast, effective relief.
Ingredients: Hemp whole plant extract, CBD* extract derived from medicinal hemp, turmeric powder, conjugated linoleic acid, white willow bark, rice concentrate, sodium bicarbonate
Medicinal Information:
Contains approximately 25mg CBD* and other cannabinoids per capsule. (*cannabidiol)
Please watch for updates to this post for more on the Dixie Dew Drops
Below Follows some Review Thoughts on the Dixie Line of Products while reviewing.
Breezy posted a photo to Dixie Elixirs‘s Wall.
I’m working on some reviews of Dixie Elixirs products… you can see some of the source images for the review by following this link… the album contains several products I am reviewing this month but features your products heavily… I’m looking forward to completing the review…. have you considered a super high potency line for severe pain patients? have you considered taking the artificial stuff out of the sodas? I only ask because there is a bit of an aftertaste but other than that I like the flavors I have sampled. ♥ The Art of Breezy Kiefair
https://www.facebook.com/photo.php?fbid=531054656914548&set=a.531053536914660.120448.100000300558421&type=3&src=https%3A%2F%2Fsphotos-a.xx.fbcdn.net%2Fhphotos-prn1%2F156236_531054656914548_2028838599_n.jpg&size=960%2C720
The clinic 3888 east mexico ave suite 110 has excellent customer service….. They really came through with nearly all the products i was asked to review and even called around just to be sure the other product wasn’t available anywhere close by. They impressed me with the look and smell of their nugs too.Really good impression overall thus far.
December 12 at 9:37am via mobile ·
December 13 at 7:17am via mobile ·
this is what the dixie elixirs website says about the drink:
While the sarsaparilla root has been used by healers for ages to treat joint pain and inflammation it is better known today as the key ingredient in a great tasting soda. Dixie Elixirs™ Old-Fashioned Sarsaparilla delivers your medicine in a comforting old-timey soda.
http://dixieelixirs.com/products/dixie-elixirs/
Strain Reviews From The Clinic Colorado
http://www.thecliniccolorado.com/locations/the-clinic-colorado
3888 E Mexico Ave
Denver, Co
(303) 758-9114
colorado@thecliniccolorado.com
Train Wreck GENETICS 10 of 10 medical leaves
For me, I always notice the neurological pain relief effects more than anything with this strain. So much so that in my early education about this strain, I always thought it was an indica. There is a rare offshoot of this strain called PaneWreck (Afghani Kush x Trainwreck) that is even more effective for me, but it can be very difficult to find. This sample of Train Wreck was just as it should be. It was full of crystals
EFFECTS
Stimulant and creative at first, intense and very stoned after a few minutes, very long-lasting.
Medicinally effective in pain therapy.
FLOWERING INDOOR
9 weeks, with a production up to 700 gr/m2.
Vine-like growth, ideal for SCRoG.
TRAIN WRECK ®
FLOWERING OUTDOOR
Ready at the beginning of October
(North hemisphere) with a production up to 800 gr/plant.
Branchy plant with vine-like growth, needs full support.
ref on strain info: http://www.greenhouseseeds.nl/shop/trainwreck-feminised.html
Luca Brasi From The Clinic on Colfax (anticipation)
10 of 10 medical leaves
Wish i could share some of this with fellow reviewer from the Toke of the Town Website Steve Elliott!!!
this strain tastes amazing! very spicy and nearly tongue numbing in a good way. feeling effects of combined high cbd and thc levels…
10 of 10 Medicinal Leaves Awarded.
Luca Brasi — 8.44 percent CBD, 10.93 percent THC
The Clinic hasn’t had the cut of Bubba Kush that took home the CBD award at the High Times Medical Cannabis Cup last April on its shelves for some time — but this Luca Brasi is the next best thing. A cross of that award-winning, 12.35 percent CBD Bubba Kush cut and Corleone OG Kush, back-crossed with the Bubba Kush, brought this powerhouse of a CBD cut to the table. Coming in at 8.44 percent CBD and 10.93 THC, this is one of the most equally balanced and overall potent cuts around town. A very strong, rubbery kush scent cut with an underlying organic-soil earthiness left my hands smelling like I’d been digging in the garden all day. The taste matched the smell perfectly, making it a pleasant puff as well as potent medication. Much more uplifting and buzzy due to the higher THC content, the strain was good for numbing the pain without knocking me down for the count. Actually, the herb had me feeling uplifted and active even after a big bowl, without any tension or anxiety, thanks to the decent THC levels. It was also good at calming nerve pain in my stomach and easing cramping after a less-than-quality street-taco session. Clinic staffers promise that the award-winning Bubba Kush will be back, but in the meantime, this is a perfectly suitable alternative. ref: http://blogs.westword.com/latestword/2011/10/medical_marijuana_cbd_tops_strains.php?page=3
Indica, AAA, 41-50, Body High, Cerebral, Strong, Long, Luca Brasi (Indica)
Check out this fun strain from The Clinic on Colfax.
Submitted By: anticipation (Member and Editor)
Camera Used: Sony Cyber-shot DSC-W290
Name: Luca Brasi
Genetics: Pre-98 Bubba Kush (CBD Pheno) X Corleone OG Kush
From: The Clinic on Colfax (Dispensary – Denver)
Grade: A+
Type: Indica
Price: $45/8th
Looks: Gorgeous chunky nugs that are frosted from end to end. Darker green calyx’s and distinctly ochre hairs give these nugs a great indica look.
Smell: I smelled kalamata olives, old pizza, and the classic kush scent in these nugs. The jar I kept them in didn’t stand a chance when it came to smell reduction, and I stunk up everything with these buds in my pocket.
Taste: Like kush, and you know that taste means a thick buzz is quick to follow. These hits gave me cotton mouth unlike anything I’ve ever smoked before though, so be forewarned and prepare your beverages accordingly.
Buzz Type: Super stoned and dumbing down effects. Not much to do but sit and enjoy the body high after a few bowls of this.
Buzz Length: Long. 2 hours.
Overall: Great pick up from the Clinic, a different kind of smoke and a really unprecedented smell in bud. I was told this strain is known for its high CBD content. It’s an acquired taste, but once you get hooked you’re a fan for life. Recommended for medical patients who need intense pain relief and enjoy heavy body highs. –anticipation
What’s with the name? Luca Brasi is a fictional character in Mario Puzo’s novel, The Godfather. –DankDiva
ref: http://reviews.nuggetry.com/buds/luca-brasi-clinic-colfax-anticipation
SAGE: Sativa Afghani Genetic Equilibrium
10 of 10 Medicinal Leaves awarded
SAGE is another one of my favorite strains…. While it is a hybrid and often I find the effects of hybrids to be a bit muddled, this strain has a strong pain relieving indica side and a strongly uplifting sativa side. another 10 of 10 leaves awarded.
dispensary where purchased:
http://www.thecliniccolorado.com/locations/the-clinic-colorado
medible company:
SAGE stands for Sativa Afghani Genetic Equilibrium, but also describes the aroma of this interesting hybrid. SAGE’s mother is a native Californian called Big Sur Holy, a sativa with a long finishing time but strong mold and bug resistance. She is combined here with a chunky Afghani indica selected for its extreme characteristics – hardiness, tight internodal structure, and fast finishing time – and grown from seed for cross breeding.
The vigorous growth, elegant leaves, straight growth pattern, and hefty weight of the Afghani balance with the pleasant, mentally aler and thoughtful sativa high, which continues to be satisfying with repeated use. A fulfilling equilibrium of the paternal lines, this plant deals well with challenging conditions, and will usually be the last plant standing in a stressed garden. SAGE holds her color and resist mite infestation.The SAGE flavor is “old-school”, reminiscent of the days when Columbian and Thai stick were still primo. The aroma is like the wild sage native to the sativa mama’s California homeland. This fresh smell is also a factor for the stealth grower – the odor doesn’t really give away its source. Even without charcoal filters, trained noses may not recognize the scent as weed.SAGE responds well to topping and is also amenable to the bend technique because the branches hold the rubbery quality of the Afghani papa. This plant likes to grow large, so it works great in beds as a larger plant but is too wily for a sea of green method. Hash made from this variety won first place ion the 1999 Cannabis Cup and scientific analysis by an unaffiliated testing facility reported that SAGE’s THC content is over 20 percent, ranking in the top 3 varieties tested.
http://www.kindgreenbuds.com/marijuana-strains/sage.htm
Related articles
- MarQaha soda, and Cannabis Xtract Capsules purchased at JP Wellness
- The Little Black Book of Marijuana by Steve Elliot book review (kiefair.com)
- Dixie X Hemp-Derived CBD Tincture Wins Top Honor at The Hemp Connoisseur Championship (prweb.com)
- Medical Marijuana Inc. and the Dixie Elixirs and Edibles Brand will be on Fox News Geraldo at Large on December 8, 2012. (sacbee.com)
- Medical marijuana businesses thrive under Colorado’s tough rules (whas11.com)
- Marijuana legalization task force meets for first time Monday (kiefair.com)
- Denver Company Wants to Take Medical-pot Elixirs National (thehandiestone.typepad.com)
- Medical marijuana businesses thrive under Colorado’s tough rules (king5.com)
Familial Mediterranean Fever ~ a Rare genetic disease
I do not look like I have a single drop of Mediterranean blood in me, so why do i care about this rare genetic disorder? Because the color of skin is only skin deep. Because despite the pale appearance of my exterior, I have the genetic ancestor from that part of the world who handed me this recessive trait. Because I have this disease and have to live with it…
I care because I need to repost the links as many times as possible in hopes that those related to me by blood will heed my warning and look for signs of the disorder in the kids…. I have made no secret of the fact that I am far estranged from my biological family, so I turn to electronic means to spread the word.
There is no cure, but the treatment does help….. There is no cure, but knowledge that there is indeed something wrong and that I am not a hypochondriac is soothing to the mind…. There is no cure, but it sure as hell does explain a lot about both myself and my blood relatives… BOTH my parents had to have the recessive gene in order for me to have this disorder. Both my parent’s sets of siblings may also be carriers of these recessive traits…. ALL of my blood siblings (half or full blooded) are POTENTIAL carriers of the defect…. Therefore, ALL of my blood nieces and nephews are potential victims of the disease as well as their children. It is my hope that those in my family will stumble upon this post and then value the family’s future generations enough to spread this information to where it may be of use (i emailed it directly to those whose email addresses I possess in my bloodline)
the below information was retrieved from: http://ghr.nlm.nih.gov/condition/familial-mediterranean-fever
What is familial Mediterranean fever?
Familial Mediterranean fever is an inherited condition characterized by recurrent episodes of painful inflammation in the abdomen, chest, or joints. These episodes are often accompanied by fever and sometimes a rash. The first episode usually occurs in childhood or the teenage years, but in some cases, the initial attack occurs much later in life. Typically, episodes last 12 to 72 hours and can vary in severity. The length of time between attacks is also variable. Without treatment to help prevent attacks and complications, a buildup of certain protein deposits (amyloidosis) in the body’s organs and tissues may occur, which can lead to kidney failure.
How common is familial Mediterranean fever?
Familial Mediterranean fever primarily affects populations originating in the Mediterranean region, particularly people of Armenian, Arabic, Turkish, and Jewish ancestry. The disorder affects from 1 in 250 people to 1 in 1,000 people in these populations. It is less common in other populations.
What genes are related to familial Mediterranean fever?
Mutations in the MEFV gene cause familial Mediterranean fever. The MEFV gene provides instructions for making a protein called pyrin (also known as marenostrin), which is found in white blood cells. This protein is involved in the immune system, helping to regulate the process of inflammation. Inflammation occurs when the immune system sends signaling molecules and white blood cells to a site of injury or disease to fight microbial invaders and facilitate tissue repair. When this has been accomplished, the body stops the inflammatory response to prevent damage to its own cells and tissues.
Mutations in the MEFV gene reduce the activity of the pyrin protein, which disrupts control of the inflammation process. An inappropriate or prolonged inflammatory response can result, usually accompanied by fever and pain in the abdomen, chest, or joints.
Normal variations in the SAA1 gene may modify the course of familial Mediterranean fever. Some evidence suggests that a particular version of the SAA1 gene (called the alpha variant) may increase the risk of amyloidosis among people with familial Mediterranean fever.
Read more about the MEFV and SAA1 genes.
How do people inherit familial Mediterranean fever?
Familial Mediterranean fever is almost always inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.
In rare cases, this condition appears to be inherited in an autosomal dominant pattern, in which one copy of the altered gene in each cell is sufficient to cause the disorder and affected individuals often inherit the mutation from one affected parent. However, there are other possible explanations of this apparent pattern. A gene mutation that occurs frequently in a population may result in a disorder with autosomal recessive inheritance appearing in multiple generations in a family, a pattern that mimics autosomal dominant inheritance. If one parent has familial Mediterranean fever (with two mutations in the MEFV gene) and the other parent is an unaffected carrier (with one mutation in the MEFV gene), it may appear as if the affected child inherited the disorder only from the affected parent. This appearance of autosomal dominant inheritance when the pattern is actually autosomal recessive is called pseudodominance.
Where can I find information about diagnosis or management of familial Mediterranean fever?
These resources address the diagnosis or management of familial Mediterranean fever and may include treatment providers.
- Gene Review: Familial Mediterranean Fever
- Gene Tests: Familial Mediterranean Fever
- MedlinePlus Encyclopedia: Familial Mediterranean fever
- MedlinePlus Encyclopedia: Secondary systemic amyloidosis
You might also find information on the diagnosis or management of familial Mediterranean fever inEducational resources and Patient support.
To locate a healthcare provider, see How can I find a genetics professional in my area? in the Handbook.
Where can I find additional information about familial Mediterranean fever?
You may find the following resources about familial Mediterranean fever helpful. These materials are written for the general public.
- MedlinePlus – Health information (3 links)
- Genetic and Rare Diseases Information Center – Information about genetic conditions and rare diseases
- Additional NIH Resources – National Institutes of Health (2 links)
- Educational resources – Information pages (3 links)
- Patient support – For patients and families (2 links)
You may also be interested in these resources, which are designed for healthcare professionals and researchers.
- Gene Reviews – Clinical summary
- Gene Tests – DNA tests ordered by healthcare professionals
- ClinicalTrials.gov – Linking patients to medical research
- PubMed – Recent literature
- OMIM – Genetic disorder catalog
What other names do people use for familial Mediterranean fever?
- Benign paroxysmal peritonitis
- Familial paroxysmal polyserositis
- FMF
- Hereditary Periodic Fever Syndromes
- Mediterranean Fever, Familial
- MEF
- Periodic Disease
- Periodic peritonitis
- Recurrent polyserositis
- Reimann periodic disease
- Siegal-Cattan-Mamou disease
- Wolff Periodic Disease
For more information about naming genetic conditions, see the Genetics Home Reference Condition Naming Guidelines and How are genetic conditions and genes named? in the Handbook.
What if I still have specific questions about familial Mediterranean fever?
Where can I find general information about genetic conditions?
The Handbook provides basic information about genetics in clear language.
- What does it mean if a disorder seems to run in my family?
- What are the different ways in which a genetic condition can be inherited?
- If a genetic disorder runs in my family, what are the chances that my children will have the condition?
- Why are some genetic conditions more common in particular ethnic groups?
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding familial Mediterranean fever?
amyloidosis ; autosomal ; autosomal dominant ; autosomal recessive ; benign ; carrier ; cell ; complication ;familial ; fever ; gene ; immune system ; inflammation ; inheritance ; injury ; joint ; kidney ; molecule ;mutation ; population ; protein ; pseudodominance ; recessive ; sign ; symptom ; syndrome ; teenage ;tissue ; white blood cells
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.
please also read:
http://emedicine.medscape.com/article/330284-overview#showall
Familial Mediterranean fever
Familial Mediterranean fever (FMF) is a hereditary inflammatory disorder[1]:149. FMF is an autoinflammatory disease caused by mutations in MEFV, a gene which encodes a 781–amino acid protein denoted pyrin.[2]
The disorder has been given various names including familial paroxysmal polyserositis, periodic peritonitis, recurrent polyserositis, benign paroxysmal peritonitis, periodic disease or periodic fever, Reimann periodic disease or Reimann’s syndrome, Siegal-Cattan-Mamou disease, and Wolff periodic disease.[3][4][5] Note that “periodic fever” can also refer to any of thePeriodic fever syndromes.
Epidemiology
FMF affects groups of people originating from around the Mediterranean Sea (hence its name). It is prominently present in the Armenian people, Sephardi Jews (and, to a much lesser extent, Ashkenazi Jews), Cypriots, Turks and Arabs.[6]
[edit]Signs and symptoms
[edit]Attacks
There are seven types of attacks. Ninety percent of all patients have their first attacks before they are 18 years old. All develop over 2–4 hours and last anywhere from 6 hours to 4 days. Most attacks involve fever.[6]
- Abdominal attacks, featuring abdominal pain, affect the whole abdomen with all signs of peritonitis (inflammation of abdominal lining), and acute abdominal pain likeappendicitis. They occur in 95% of all patients and may lead to unnecessary laparotomy. Incomplete attacks, with local tenderness and normal blood tests, have been reported.
- Joint attacks mainly occur in large joints, especially in the legs. Usually, only one joint is affected. Seventy-five percent of all FMF patients experience joint attacks.
- Chest attacks include pleuritis (inflammation of the pleura) and pericarditis (inflammation of the pericardium). Pleuritis occurs in 40% of patients, and makes it difficult to breathe or lie flat, but pericarditis is rare.
- Scrotal attacks due to inflammation of the tunica vaginalis occurs in up to 5% and may be mistaken for acute scrotum (i.e. testicular torsion).
- Myalgia (rare in isolation)
- Erysipeloid (a skin reaction on the legs, rare in isolation)
- Fever without any of the other symptoms listed above (25%)
[edit]Complications
AA-amyloidosis with renal failure is a complication and may develop without overt crises. AA amyloid protein is produced in very large quantities during attacks, and at a low rate between them, and accumulates mainly in the kidney, as well as the heart, spleen, gastrointestinal tract and thyroid.[6]
There appears to be an increase in the risk for developing particular vasculitis-related diseases (e.g. Henoch-Schönlein purpura), spondylarthropathy, prolonged arthritis of certain joints and protracted myalgia.[6]
[edit]Diagnosis
The diagnosis is clinically made on the basis of the history of typical attacks, especially in patients from the ethnic groups in which FMF is more highly prevalent. An acute phase response is present during attacks, with high C-reactive protein levels, an elevated white blood cell count and other markers of inflammation. In patients with a long history of attacks, monitoring the renal function is of importance in predicting chronic renal failure.[6]
A genetic test is also available to detect mutations in the MEFV gene. Sequencing of exons 2, 3, 5, and 10 of this gene detects an estimated 97% of all known mutations.[6]
A specific and highly sensitive test for FMF is the “Metaraminol Provocative Test (MPT),” whereby a single 10 mg infusion of Metaraminol is administered to the patient. A positive diagnosis is made if the patient presents with a typical, albeit milder, FMF attack within 48 hours. As MPT is more sensitive than specific, it does not identify all cases of FMF. Although a positive MPT can be very useful.[7][8]
[edit]Pathophysiology
Virtually all cases are due to a mutation in the MEFV gene on the sixteenth chromosome, which codes for a protein called pyrin or marenostrin. Various mutations of this gene lead to FMF, although some mutations cause a more severe picture than others. Mutations occur mainly in exons 2, 3, 5 and 10.[6]
The function of pyrin has not been completely elucidated, but it appears to be a suppressor of the activation of caspase 1, the enzyme that stimulates production of interleukin 1β, a cytokine central to the process of inflammation. In other words an ineffective pyrin doesn’t inhibit inflammation normally, resulting in inflammatory episodes of membranes at differing sites. It is not conclusively known what exactly sets off the attacks, and why overproduction of IL-1 would lead to particular symptoms in particular organs (e.g. joints or the peritoneal cavity).[6]
[edit]Genetics
The MEFV gene is located on the short arm of chromosome 16 (16p13). The disorder inherits in an autosomal recessive fashion. Therefore, two asymptomatic carrier parents have a 25% chance of a child with the disorder, a 50% chance of a child who is an asymptomatic carrier and a 25% chance of a child who does not carry the disorder. FMF patients who have children with a carrier or another FMF patient have a 50% and 100% chance, respectively, of having a child with FMF.[9][10]
There is one known case of an affected patient with only one parent who is a carrier. This is caused by a unique mutation on thesixteenth chromosome.
[edit]Treatment
Attacks are self-limiting, and require analgesia and NSAIDs (such as diclofenac).[6]
Colchicine, a drug otherwise mainly used in gout, decreases attack frequency in FMF patients. The exact way in which colchicine suppresses attacks is unclear. While this agent is not without side effects (such as abdominal pain and muscle pains), it may markedly improve quality of life in patients. The dosage is typically 1–2 mg a day. Development of amyloidosis is delayed with colchicine treatment. Interferon is being studied as a therapeutic modality.[6] Some advise discontinuation of colchicine before and during pregnancy, but the data are inconsistent, and others feel it is safe to take colchicine during pregnancy.[11]
Approximately 5-10% of FMF cases are resistant to colchicine therapy alone. In these cases, adding anakinra to the daily colchicine regimen has been successful.[12]
[edit]History
A New York allergist, Dr Sheppard Siegal, first described the attacks of peritonitis in 1945; he termed this “benign paroxysmal peritonitis”, as the disease course was essentially benign.[13] Dr Hobart Reimann, working in the American University in Beirut, described a more complete picture which he termed “periodic disease”.[14][15]
In 1972, colchicine was discovered to prevent attacks.[16]
The link to the MEFV gene was discovered in 1997 by two different groups, each working independently – the French FMF Consortium,[9] and the International FMF Consortium.[10]
[edit]See also
[edit]References
- ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews’ Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
- ^ Chae JJ, Wood G, Richard K et al. (September 2008). “The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment”. Blood 112 (5): 1794–1803. doi:10.1182/blood-2008-01-134932. PMC 2518886. PMID 18577712.
- ^ Dugdale III, David C; Jatin Vyas (2010-09-15). “Familial Mediterranean fever – PubMed Health”. PubMed Health. National Centre for Biotechnology Information. Retrieved 2011-04-24.
- ^ Enersen, Ole Daniel. “Whonamedit – Siegal-Cattan-Mamou syndrome”. Whonamedit? A dictionary of medical eponyms. Archived from the original on 2001-04-24. Retrieved 2011-04-24.
- ^ “Familial Mediterranean fever – Genetics Home Reference”. Genetics Home Reference. U.S. National Library of Medicine. 2011-04-14. Archived from the original on 2011-04-24. Retrieved 2011-04-24.
- ^ a b c d e f g h i j Livneh A, Langevitz P (2000). “Diagnostic and treatment concerns in familial Mediterranean fever”. Baillieres Best Pract Res Clin Rheumatol 14 (3): 477–498.doi:10.1053/berh.2000.0089. PMID 10985982.
- ^ Barakat MH, El-Khawad AO, Gumaa KA, El-Sobki NI, Fenech FF (1984). “Metaraminol provocative test: a specific diagnostic test for familial Mediterranean fever”. Lancet 1(8378): 656–7. PMID 6142351.
- ^ Huppertz HI, Michels H (1988). “[The metaraminol provocation test in the diagnosis of familial Mediterranean fever]”. Monatsschr Kinderheilkd 136 (5): 243–5. PMID 3405225.
- ^ a b The French FMF Consortium (1997). “A candidate gene for familial Mediterranean fever”. Nat. Genet. 17 (1): 25–31. doi:10.1038/ng0997-25. PMID 9288094.
- ^ a b The International FMF Consortium (1997). “Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever”. Cell 90(4): 797–807. doi:10.1016/S0092-8674(00)80539-5. PMID 9288758.
- ^ Michael O, Goldman RD, Koren G (August 2003). “Safety of colchicine therapy during pregnancy”. Can Fam Physician 49: 967–9. PMC 2214270. PMID 12943352.
- ^ Calligaris L, Marchetti F, Tommasini A, Ventura A (2008). “The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever”. European Journal of Pediatrics 167 (6): 695–696. doi:10.1007/s00431-007-0547-3. PMC 2292480. PMID 17588171.
- ^ Siegal S (1945). “Benign paroxysmal peritonitis”. Ann Intern Med 23 (2): 234–47. PMID 18124924.
- ^ Reiman HA (1948). “Periodic disease. Probable syndrome including periodic fever, benign paroxysmal peritonitis, cyclic neutropenia and intermittent arthralgia”. J Am Med Assoc 136 (4): 239–44. PMID 18920089.
- ^ synd/2503 at Who Named It?
- ^ Goldfinger, S.E. (1972-12-21). “Colchicine for familial Mediterranean fever”. New England Journal of Medicine 287 (25): 1302. doi:10.1056/NEJM197212212872514.PMID 4636899.
[edit]External links
- Proteopedia 2wl1 information about the MEFV gene.
- GeneReview/NIH/UW entry on Familial Mediterranean Fever
Breezy Says:
–Auto signature below–
Respectfully,
Breedheen O’Rilley Keefer
AKA Breezy Kiefair
links about breezy
blog
http://misshightimes.com/users/breezykiefair
on youtube
http://www.youtube.com/user/Mr8MrsKiefAir?feature=mhsn
art “like” page on FB
http://www.facebook.com/pages/The-Art-of-Breezy-Kiefair/154533251224064
fb profile
http://www.facebook.com/breezy.kiefair
@breezykiefair
the short 4 page version:
http://www.scribd.com/doc/64585079/My-Personal-Christmas-Present-to-the
shine out from you, and plant the seed of peace in other spirits, for them
to cultivate.~{Remember… it is when we choose act on the issues that are in front of
our faces, when we choose to get involved instead of looking the other way
as our fellow man struggles, when we choose to take those small simple
little actions, working on righting little wrongs in our everyday lives that
really make change happen, those seemingly small actions are what really
make the world a better place and are a catalyst for greater social change.}
~Both quotes by Breedheen “Bree” O’Rilley Keefer~
Related articles
- A Family Doctor’s Tale – GENETIC DISEASES (kennethkee.info)
- Mechanisms Behind Fever-Induced Seizures Revealed By New Fruit Fly Model Of Epilepsy (medicalnewstoday.com)
- Could genetic diseases be cured in the womb? (sott.net)
- Colchicine in Renal Failure (sajerosablog.wordpress.com)
- Interesting article about CVID and Genes (cvidarticles.wordpress.com)
- Licorice Shown To Kill SARS And Other Lethal Viruses (vaticproject.blogspot.com)
- Polyposis (familyhistorybowelcancer.wordpress.com)
- Researcher Investigates His Own Genetic Mutation (23andme.com)
At Home Baked Baked at home revisited: Gluten Free & Blondie
June 15, 2012
Gluten Free Medicated Brownies from At Home Baked
video review: At Home Baked LLC’s Gluten Free medicated brownies read the previous review here http://breedheenorilleykeefer.com/2012/04/04/at-home-baked-baked-at-home/
You can find out where you can pick up a box of brownie mix at the At Home Baked website. http://www.athomebakedcolorado.com/
other reviews and testimonials of this product: http://www.athomebakedcolorado.com/patient-reviews-testimonials/ http://nugs.com/article/edibles-review-at-home-baked-brownie-mix.html NEW REVIEW VIDS TO FOLLOW! __________________________________________________
June 17, 2012
Baking the Blondies from At Home Baked
please read this article on the benefits of hemp seed!
Review
2012-06-18 at home baked blondies review 10 of 10!
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
I’ll end with my previous review of At Home Baked
*****NOTE***** when I wrote this, I had an UN-DIAGNOSED BROKEN PELVIS!
At Home Baked, Baked at Home Before I begin my review of these brownies, let me set the stage… It’s spring in the Colorado Rockies. We’ve had some lovely weather, and I have overexerted myself into intractable pain. A storm begins to move over the mountains threatening our warm weather. I’ve been pushing through the intractable pain and working with the aid of cannabis hash oil made in the Rick Simpson method, but am still aching. I watch the storm growing ever closer and begin to wish for sleep. Then I remember a gift from ReverendPartridge. I happen to have a box of indica “At Home Baked” Brownies. The good reverend had put them into my hands as a mercy and asked me to try them. So, I hobble into the kitchen with my box of compassion to bake up some mercy. I read the instructions on the box which are as follows:
Baking Instructions
For your At Home Baked experience you need:
A Box of At Home Baked Brownies or Blondies
2 eggs
a little butter or oil to grease baking pan
an 8×8 or 9×9 baking pan
a large mixing bowl
mixing spoon or whisk
- Pre-heat oven to 350 degrees.
- Grease 8×8 or 9×9 baking pan.
- Place dry ingredients into large mixing bowl.
- Shake oil packet then add and mix evenly (about 20 strokes)
- Add eggs one at a time and finish mixing (30 more strokes)
- Spread mixed batter into baking pan.
- Bake @ 350 Degrees until center sets Approx. 25-35min in 8×8 or 20-30min in 9×9 pan
- Let cool then enjoy with caution!
A little goes a long way!
If you aren’t sure weather they are done or not use a toothpick and poke the middle of the mix if it is mostly clean they are done if it is covered in fudgy goodness they need a few more minuets.
(retrieved from: http://www.athomebakedcolorado.com/baking-instructions/ )
About ten minutes later, they were in the oven, about a half an hour after that, they came out of the oven. I cut the brownies into 8 pieces as directed by the box. As soon as they were cool enough, I plated the brownies and some fresh strawberries and a cup of tea. The brownie’s flavor was decadent rich chocolate on the palate with the familiar notes of cannabis in proper balance with the other flavors. It was enjoyable to eat, but so rich I would recommend you have a drink handy when you serve one to yourself or your patient. Most people would say a glass of milk, but I opted for some tea. I was still awake and in pain an hour and a half later, however I was also capable of laughter. I had not been capable of laughing in some time. This was an improvement. Eager and hoping to achieve an end to the intractable pain shooting through my body, I plated up another brownie. Just as I began munching on the second brownie, snow began falling and I understood why I was having issue getting on top of my pain. It had to be the impending storm making it so difficult to get comfortable. In the end, I ate a nearly half a pan of brownies. I was up most of the night, but once the storm slowed and I found sleep, I did sleep for an increased duration compared with my usual sleep patterns. Before you think this is a negative review, let me remind you of the definition of intractable:
Definition of INTRACTABLE
1
: not easily governed, managed, or directed <intractable problems>
2
: not easily manipulated or wrought<intractable metal>
3
: not easily relieved or cured <intractable pain>
(retrieved from: http://www.merriam-webster.com/dictionary/intractable )
The fact that these brownies were able to make me laugh when I was in so much pain is a strong indication to me of a good product. Another Carded individual in the house was asleep within 30 minutes of eating 1 brownie. My assessment, 10 of 10 Medicinal Leaves Awarded! You can find out where you can pick up a box of brownie mix at the At Home Baked website. http://www.athomebakedcolorado.com/
other reviews and testimonials of this product: http://www.athomebakedcolorado.com/patient-reviews-testimonials/ http://nugs.com/article/edibles-review-at-home-baked-brownie-mix.html
_____________________________________________________________
latest fat freddy video:
————————————————————————————————-
Related articles
- At Home Baked, Baked at Home (breedheenorilleykeefer.com)
- The History of Brownies in the United States (berries.com)